Ramipex 0.25/Ramipex 1 Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Concise Prescribing Info

Contents

Pramipexole HCl

Indications/Uses

Management of Parkinson's disease either alone or as an adjunct to levodopa therapy to reduce end-of-dose or on-off fluctuations in response.

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Dosage/Direction for Use

Initially 0.375 mg/day in 3 divided doses, should not increase more frequently than every 5-7 days. Ascending dosage schedule Wk 1: 0.125 mg tid. Wk 2: 0.25 mg tid. Wk 3: 0.5 mg tid. Wk 4: 0.75 mg tid. Wk 5: 1 mg tid. Wk 6: 1.25 mg tid. Wk 7: 1.5 mg tid. Maintenance 1.5-4.5 mg/day in equally divided doses tid. Patient w/ renal impairment CrCl >50 mL/min Starting dose: 0.125 mg tid. Max: 1.5 mg tid. CrCl 30-50 mL/min Starting dose: 0.125 mg bid. Max: 0.75 mg tid. CrCl 15-30 mL/min Starting dose: 0.125 mg once daily. Max: 1.5 mg once daily. Discontinuation of treatment May be tapered off at a rate of 0.75 mg/day then by 0.375 mg/day if the dose has been reduced to 0.75 mg.

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Overdosage

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Administration

May be taken with or without food.

Contraindications

Hypersensitivity.

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Special Precautions

Regular ophth monitoring if vision abnormalities occur. Monitor for signs & symptoms of orthostatic hypotension. Compulsive behaviors; hallucinations & psychotic-like behavior; dyskinesia & melanoma may occur. Risk of neuroleptic malignant syndrome w/ abrupt w/drawal. May impair ability to drive or operate machinery. Renal impairment. Pregnancy & lactation.

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Use In Pregnancy & Lactation

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Adverse Reactions

Dizziness, dyskinesia, somnolence; hypotension; nausea. Abnormal dreams, behavioral symptoms of impulse control disorders & compulsions, confusion, hallucinations, insomnia, restlessness; amnesia, headache; visual disturbance eg, blurred vision & reduced visual acuity; constipation, vomiting; fatigue, peripheral oedema; decreased wt.

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Drug Interactions

Reduced renal clearance w/ cimetidine. Decreased oral clearance w/ ranitidine, diltiazem, triamterene, verapamil, quinidine, quinine; cisplatin & procainamide; & amantadine. Possible additive effects & risk of precipitating sudden onset of sleep w/ other sedating drugs or alcohol.

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Storage

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Description

View Ramipex 0.25/Ramipex 1 description for details of the chemical structure and excipients (inactive components).

Action

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MIMS Class

Antiparkinsonian Drugs

ATC Classification

N04BC05 - pramipexole ; Belongs to the class of dopamine agonist. Used in the management of Parkinson's disease.

Regulatory Classification

Presentation/Packing

Form

Ramipex 0.25 tab 250 mcg

Packing/Price

30's (P1,039.5/box)

Form

Ramipex 1 tab 1 mg

Packing/Price

30's (P2,509.5/box)

Ramipex 0.25/Ramipex 1

pramipexole

Manufacturer:

Torrent

Distributor:

Torrent